Tan, Siew Kiat * and Pippen, Richard and Rohana Yusof, and Halijah Ibrahim, and Norzulaani Khalid, and Noorsaadah Abd Rahman, (2006) Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Bioorganic & Medicinal Chemistry Letters, 16 (12). pp. 3337-40.
Full text not available from this repository.Abstract
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
| Item Type: | Article |
|---|---|
| Additional Information: | Second author is affiliated with Western Michigan University; third to sixth authors are affiliated with University of Malaya. |
| Uncontrolled Keywords: | Boesenbergia rotunda (L.) extracts; Cyclohexenyl chalcone derivatives; Dengue 2; NS3 protease; Competitive inhibitory activities |
| Subjects: | Q Science > QK Botany R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Depositing User: | Administrator Admin |
| Date Deposited: | 15 Oct 2012 06:33 |
| Last Modified: | 30 Jan 2018 02:42 |
| URI: | http://eprints.sunway.edu.my/id/eprint/32 |
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