Amrutha, Menon and Noraini, Abd-Aziz * and Kanwal, Khalid * and Poh, Chit Laa * and Rakesh, Naidu (2022) miRNA: A Promising Therapeutic Target in Cancer. International Journal of Molecular Sciences, 23 (19). ISSN 1422-0067
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Poh Chit Laa_miRNA a promising therapeutic target in cancer.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy.
| Item Type: | Article |
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| Uncontrolled Keywords: | cancer; miRNA; miRNA delivery; oncomiR; therapy; tumor suppressor; |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Microbiome Centre [formerly Centre for Virus and Vaccine Research until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 12 Aug 2024 08:42 |
| Last Modified: | 12 Aug 2024 08:42 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3078 |
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