Cheung, Johnny T K and Lau, Eric and Tsui, Cyrus C T and Siu, Edmond L N and Tse, Naomi K W and Hui, Nicole Y L and Mo, Ronald C W and Kong, Alice P S and Fu, Amy and Lau, Vanessa and Jia, Weiping and Sheu, Wayne H H and Sobrepena, Leorino and Yoon, K H and Tan, Alexander T B and Chia, Yook Chin * and Sosale, Aravind and Saboo, Banshi D and Kesavadev, Jothydev and Goh, Su Yen and Nguyen, Thy Khue and Thewjitcharoen, Yotsapon and Suwita, Raymond and Luk, Andrea O Y and Yang, Aimin and Chow, Elaine and Lim, Lee Ling and Chan, Juliana C N (2022) Combined associations of family history and self-management with age at diagnosis and cardiometabolic risk in 86,931 patients with type 2 diabetes: Joint Asia Diabetes Evaluation (JADE) Register from 11 countries. BMC Medicine, 249. ISSN 1741-7015
Full text not available from this repository. (Request a copy)Abstract
Background: Family history (FamH) of type 2 diabetes might indicate shared genotypes, environments, and/or behaviors. We hypothesize that FamH interacts with unhealthy behaviors to increase the risk of early onset of diabetes and poor cardiometabolic control. Methods: In a cross-sectional analysis of the prospective Joint Asia Diabetes Evaluation Register including patients from 427 clinics in 11 Asian countries/regions in 2007-2021, we defined positive FamH as affected parents/siblings and self-management as (1) healthy lifestyles (balanced diet, non-use of alcohol and tobacco, regular physical activity) and (2) regular self-monitoring of blood glucose (SMBG). Results: Among 86,931 patients with type 2 diabetes (mean±SD age: 56.6±11.6 years; age at diagnosis of diabetes: 49.8±10.5 years), the prevalence of FamH ranged from 39.1% to 85.3% in different areas with FamH affecting mother being most common (32.5%). The FamH group (n=51,705; 59.5%) was diagnosed 4.6 years earlier than the non-FamH group [mean (95% CI): 47.9 (47.8-48.0) vs. 52.5 (52.4-52.6), logrank p<0.001]. In the FamH group, patients with both parents affected had the earliest age at diagnosis [44.6 (44.5-44.8)], followed by affected single parent [47.7 (47.6-47.8)] and affected siblings only [51.5 (51.3-51.7), logrank p<0.001]. The FamH plus ≥2 healthy lifestyle group had similar age at diagnosis [48.2 (48.1-48.3)] as the non-FamH plus <2 healthy lifestyle group [50.1 (49.8-50.5)]. The FamH group with affected parents had higher odds of hyperglycemia, hypertension, and dyslipidemia than the FamH group with affected siblings, with the lowest odds in the non-FamH group. Self-management (healthy lifestyles plus SMBG) was associated with higher odds of attaining HbA1c<7%, blood pressure<130/80mmHg, and LDL-C<2.6 mmol/L especially in the FamH group (FamH×self-management, pinteraction=0.050-0.001). Conclusions: In Asia, FamH was common and associated with young age of diagnosis which might be delayed by healthy lifestyle while self management was associated with better control of cardiometabolic risk factors especially in those with FamH.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | age of diagnosis; cardiometabolic risks; family history; self-management; type 2 diabetes. |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 12 Aug 2024 01:21 |
| Last Modified: | 12 Aug 2024 01:21 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3061 |
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