Fuloria, Shivkanya and Mehta, Jyoti and Chandel, Aditi and Mahendran, Sekar and Nur Najihah, Izzati Mat Rani and Begum, M Yasmin and Vetriselvan, Subramaniyan and Chidambaram, Kumarappan and Thangavelu, Lakshmi and Rusli, Bin Nordin and Wu, Yuan Seng * and Kathiresan, V Sathasivam and Lum, Pei Teng and Meenakshi, Dhanalekshmi Unnikrishnan and Vinoth, Kumarasamy and Abdul Kalam, Azad and Fuloria, Neeraj Kumar (2022) A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin. Frontiers in Pharmacology, 13. ISSN 1663-9812
Full text not available from this repository. (Request a copy)Abstract
Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constituent of C. longa, is well known for its therapeutic potential in numerous disorders. However, there is a lack of literature on the therapeutic potential of C. longa in contrast to curcumin. Hence, the present review aimed to provide in-depth information by highlighting knowledge gaps in traditional and scientific evidence about C. longa in relation to curcumin. The relationship to one another in terms of biological action includes their antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective, immunomodulatory, antifertility, antimicrobial, antiallergic, antidermatophytic, and antidepressant properties. Furthermore, in-depth discussion of C. longa on its taxonomic categorization, traditional uses, botanical description, phytochemical ingredients, pharmacology, toxicity, and safety aspects in relation to its major compound curcumin is needed to explore the trends and perspectives for future research. Considering all of the promising evidence to date, there is still a lack of supportive evidence especially from clinical trials on the adjunct use of C. longa and curcumin. This prompts further preclinical and clinical investigations on curcumin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Curcuma longa; curcumin; pharmacology; phytochemical; toxicology; |
| Subjects: | Q Science > QK Botany R Medicine > RA Public aspects of medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Microbiome Centre [formerly Centre for Virus and Vaccine Research until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 08 Aug 2024 05:10 |
| Last Modified: | 08 Aug 2024 05:10 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3035 |
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