Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B

Low, Wei Feng * and Ngeow, Yun Fong and Chook, Jack Bee * and Tee, Kok Keng and Ong, Seng Kai * and Peh, Suat Cheng * and Bong, Jan Jin and Rosmawati, Mohamed (2023) Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B. Expert Reviews in Molecular Medicine, 25. ISSN 1462-3994

Full text not available from this repository.

Abstract

Hepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis.

Item Type:	Article
Uncontrolled Keywords:	biomarker; chronic hepatitis B; covalently closed circular DNA; CpG islands; hepatitis B virus; hepatocellular carcinoma; methylation;
Subjects:	Q Science > QH Natural history R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences
Depositing User:	Ms Yong Yee Chan
Related URLs:	Author Author Author Author
Date Deposited:	16 Jul 2024 00:27
Last Modified:	16 Jul 2024 00:27
URI:	http://eprints.sunway.edu.my/id/eprint/2817

Actions (login required)

View Item