Nur Izreena, Ismail and Khairul Najmi, Muhammad Nawawi and Chew, Deborah Chia Hsin and Kok, Wei Hao and Nik Ritza, Kosai Nik Mahmood and Lee, Gary Chong Chearn and Wong, Zhiqin and Azmi, Mohd Tamil and Joseph, Hazel and Raja Affendi, Raja Ali * (2023) Probiotic containing Lactobacillus reuteri DSM 17648 as an adjunct treatment for Helicobacter pylori infection: A randomized, double-blind, placebo-controlled trial. Helicobacter, 28 (6). ISSN 1523-5378
Full text not available from this repository. (Request a copy)Abstract
Background: Despite multiple therapy regimens, the decline in the Helicobacter pylori eradication rate poses a significant challenge to the medical community. Adding Lactobacillus reuteri probiotic as an adjunct treatment has shown some promising results. This study aims to investigate the efficacy of Lactobacillus reuteri DSM 17648 in H. pylori eradication and its effect in ameliorating gastrointestinal symptoms and adverse treatment effects. Materials and methods: This randomized, double-blinded, placebo-controlled trial involved treatment-naïve H. pylori-positive patients. Ninety patients received standard triple therapy for 2 weeks before receiving either a probiotic or placebo for 4 weeks. The posttreatment eradication rate was assessed via a 14 C urea breath test in Week 8. The Gastrointestinal Symptom Rating Scale (GSRS) questionnaire and an interview on treatment adverse effects were conducted during this study. Results: The eradication rate was higher in the probiotic group than in the placebo group, with a 22.2% difference in the intention-to-treat analysis (91.1% vs. 68.9%; p = 0.007) and 24.3% difference in the per-protocol analysis (93.2% vs. 68.9%; p = 0.007). The probiotic group showed significant pre- to post-treatment reductions in indigestion, constipation, abdominal pain, and total GSRS scores. The probiotic group showed significantly greater reductions in GSRS scores than the placebo group: indigestion (4.34 ± 5.00 vs. 1.78 ± 5.64; p = 0.026), abdominal pain (2.64 ± 2.88 vs. 0.89 ± 3.11; p = 0.007), constipation (2.34 ± 3.91 vs. 0.64 ± 2.92; p = 0.023), and total score (12.41 ± 12.19 vs. 4.24 ± 13.72; p = 0.004). The probiotic group reported significantly fewer adverse headache (0% vs. 15.6%; p = 0.012) and abdominal pain (0% vs. 13.3%; p = 0.026) effects. Conclusions: There was a significant increase in H. pylori eradication rate and attenuation of symptoms and adverse treatment effects when L. reuteri was given as an adjunct treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Helicobacter pylori; Lactobacillus reuteri; GSRS; eradication; gastrointestinal symptom rating scale; probiotics; |
| Subjects: | Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > SMLS Admin |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 08 Jul 2024 03:23 |
| Last Modified: | 08 Jul 2024 03:23 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2756 |
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