Lee, Michelle Felicia * and Poh, Chit Laa * (2023) Strategies to improve the physicochemical properties of peptide‑based drugs. Pharmaceutical Research. ISSN 0724-8741
Full text not available from this repository. (Request a copy)Abstract
Peptides are a rapid-growing class of therapeutics with unique and desirable physicochemical properties. Due to disadvantages such as low membrane permeability and susceptibility to proteolytic degradation, peptide-based drugs have limited bioavailability, a short half-life, and rapid in vivo elimination. Various strategies can be applied to improve the physicochemical properties of peptide-based drugs to overcome limitations such as limited tissue residence time, metabolic instability, and low permeability. Applied strategies including backbone modifcations, side chain modifcations, conjugation with polymers, modifcation of peptide termini, fusion to albumin, conjugation with the Fc portion of antibodies, cyclization, stapled peptides, pseudopeptides, cell-penetrating peptide conjugates, conjugation with lipids, and encapsulation in nanocarriers are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chemical modification; drug delivery; nanoparticles; nanotechnology peptides |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre for Virus and Vaccine Research [dissolved] |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 20 Mar 2023 03:56 |
| Last Modified: | 20 Mar 2023 03:56 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2159 |
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