Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype

Baig, A.M and Lalani, S and Khan, Naveed Ahmed * (2017) Apoptosis in Acanthamoeba castellanii belonging to the T4 genotype. Journal of Basic Microbiology, 9999. pp. 1-6. ISSN 0233 111X

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Abstract

Here we describe features of apoptosis in unicellular Acanthamoeba castellanii belonging to the T4 genotype. When exposed to apoptosis-inducing compounds such as doxorubicin, A. castellanii trophozoites exhibited cell shrinkage and membrane blebbing as observed microscopically, DNA fragmentation using agarose gel electrophoresis, and phosphatidylserine (PS) externalization using annexinVimmunostaining. Overall,thesefindingssuggesttheexistenceofapoptosis inA.castellaniipossiblymediatedbyintrinsicapoptoticcascade.Furtherresearchin this field could provide avenues to selectively induce apoptosis in A. castellanii by triggering intrinsic apoptotic cascade.

Item Type: Article
Uncontrolled Keywords: Acanthamoeba; annexin V; apoptosis; DNA fragmentation
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Divisions: Sunway University > School of Science and Technology > Dept. Biological Sciences
Depositing User: Dr Janaki Sinnasamy
Date Deposited: 30 May 2017 10:06
Last Modified: 30 May 2017 10:06
URI: http://eprints.sunway.edu.my/id/eprint/494

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