Bhupatiraju, Lakshmi and Bethala, Krupavaram and Goh, Khang Wen and Dhaliwal, Jagjit Singh and Siang, Tan Ching and Shasidharan, Menon and Bama, V.V. Menon and Kishore, Babu Anchu and Chan, Siok Yee and Long, Chiau Ming * and Khan, Abdullah (2023) Influence of Murraya koenigii extract on diabetes induced rat brain aging. Journal of Medicine and Life, 16 (2). ISSN 1844-3117
Full text not available from this repository. (Request a copy)Abstract
Food supplements are used to improve cognitive functions in age-related dementia. This study was designed to determine the Murraya koenigii leaves’ effect on Alloxan-induced cognitive impairment in diabetic rats and the contents of oxidative stress biomarkers, catalase, reduced glutathione, and glutathione reductase in brain tissue homogenates. Wistar rats were divided into seven groups (six rats per group). Group I received saline water (1 ml, p.o.), Diabetes was induced in Groups II–VII with Alloxan (120 mg/kg/p.o). Group III was provided with Donepezil HCl (2.5 mg/kg/p.o.), Group IV, V, VI, and VII with Murraya koenigii ethanol extract (200 and 400 mg/kg/p.o.) and aqueous extract (200 and 400 mg/kg/p.o.), respectively, for 30 days. Behavior, acetylcholinesterase (AChE) activity, oxidative stress status, and histopathological features were determined in the hippocampus and cerebral cortex. Administration of Murraya koenigii ethanolic and aqueous extracts significantly (P<0.05, P<0.001) increased the number of holes crossed by rats from one chamber to another. There was an increase in the (1) latency to reach the solid platform, (2) number of squares traveled by rats on the 30th day, and (3) percentage of spontaneous alternation behavior compared to the control group. Administration for successive days markedly decreased AChE activity (P<0.05), decreased TBARS level, and increased catalase, GSH, and GR levels. Murayya koenigii could be a promising food supplement for people with dementia. However, more research into sub-chronic toxicity and pharmacokinetic and pharmacodynamics interactions is essential.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Murraya koenigii; diabetes; dementia; neurodegeneration; oxidative stress; anti-oxidant; nootropic; |
| Subjects: | Q Science > QK Botany R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine S Agriculture > SB Plant culture |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 29 Jul 2024 00:39 |
| Last Modified: | 29 Jul 2024 00:39 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2912 |
Actions (login required)
 |
View Item |
