Biria, Marjan and Banca, Paula and Healy, Mairead P. and Keser, Engin and Sawiak, Stephen J. and Rodgers, Christopher T. and Rua, Catarina and de Souza, Ana Maria Frota Lisboa Pereira and Aleya, A Marzuki * and Sule, Akeem and Ersche, Karen D. and Robbins, Trevor W. (2023) Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls. Nature Communications, 14. ISSN 2041-1723
Full text not available from this repository.Abstract
There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anterior cingulate cortex; ACC; supplementary motor area; SMA; obsessive-compulsive disorder; OCD; GABA |
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 24 Jun 2024 07:48 |
| Last Modified: | 24 Jun 2024 07:48 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2688 |
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