Salhi, Najoua and El Guourrami, Otman and Balahbib, Abdelaali and Rouas, Lamiae and Moussaid, Siham and Moutawalli, Amina and Benkhouili, Fatima Zahra and Ameggouz, Mouna and Ullah, Riaz and Alotaibi, Amal and Bouyahya, Abdelhakim and Tan, Ching Siang and Long, Chiau Ming * and El Abbes Faouzi, My * and Cherrah, Yahya (2024) Application of Aleppo pine extract for skin burn treatment. Journal of Applied Biomaterials & Functional Materials, 22. ISSN 2280-8000
Full text not available from this repository. (Request a copy)Abstract
Objective: To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns. Methods: Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation. Results: In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns. Conclusion: This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pinus halepensis; angiogenesis; antibacterial activity; inflammation; skin burn; |
| Subjects: | Q Science > QK Botany Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 11 Jun 2024 02:50 |
| Last Modified: | 11 Jun 2024 02:50 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2655 |
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