Mohamed Hassan Saad, Abdella (2022) Exploration of gallic acid derivatives towards multidrug-resistant pathogens: docking, synthesis and biological evaluation. Masters thesis, Sunway University.
Full text not available from this repository.Abstract
This study aims to explore the potential of gallic acid derivatives towards multi-drug resistance (MDR) Salmonella enterica and ESKAPE pathogens. Different research approaches have been employed to accelerate the discovery process including molecular docking, chemical organic synthesis, antimicrobial activity testing, and cytotoxicity testing. Thirteen compounds were docked, synthesized with moderate to excellent yield, and evaluated against various pathogenic bacteria. Compound 13 was found to be the most potent exhibiting antimicrobial activity in 6 out of 7 of the tested bacteria (Salmonella enterica, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa). The minimum inhibitory concentrations (MIC) values of compound 13 ranging from 475 μg/mL to 2000 μg/mL. Compound 13 showed no cytotoxic effect against human embryonic kidney cells even with a concentration of 5000 μg/mL. While compound 6 might be a good candidate against Staphylococcus aureus as the MIC was 56 μg/mL as at this active concentration no cytotoxicity was found against human embryonic kidney cells. Compounds 2-4, and 11, exhibited the MICs at 1700 μg/mL, 1680 μg/mL, 1000 μg/mL, and 2000μg/mL respectively against Acinetobacter baumannii. Compound 5 showed a MIC of 1540 μg/mL against Staphylococcus aureus. Compounds 2-5 and 11 were all cytotoxic against human embryonic kidney cells.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | gallic acid derivatives; multi-drug resistance; MDR; molecular docking; MIC; antimicrobial activity; minimum inhibitory concentrations |
| Subjects: | Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 08 Oct 2023 23:48 |
| Last Modified: | 08 Oct 2023 23:48 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2446 |
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