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primary topic: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells

Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells
type: Thesis
type: Article
abstract: Breast cancer is regarded as a major global health issue due to its high incidence and mortality rate. They are also becoming harder to treat due to the emergence of multidrug resistance (MDR), rendering anticancer drugs less sensitive than ever. Therapeutic nanoparticles and novel bio-derived drugs can be used as a potential replacement for chemo-drug-resistant breast cancer. This study was performed to investigate the resistance of breast cancer cells against a multitude of drugs, as well as to evaluate whether certain nanoparticles could induce cytotoxicity. Four antineoplastic agents, Cisplatin (CDDP), Paclitaxel (PTX), Alpha-Mangostin (A-MG), and Andrographolide (Andr-G), as well as three nanoparticles, synthesized gold nanoparticles (AuNPs), silver nanoparticles (AgNPs), and graphene oxide (GO), were investigated for cytotoxicity against non-chemo-resistant breast cancer MCF-7, chemo-resistant MCF-7-CR, and MDR MDA-MB-231 cell lines. AuNPs and AgNPs were synthesized via chemical reduction using reducing agents NaBH4 and ascorbic acid, where they were further characterized. Treatment of GO was coupled with UV-B irradiation to determine the influence on cytotoxicity against breast cancer cells. It was found that PTX was the most potent yet easiest to be desensitized among all four drugs, whereas A-MG and Andr-G were less prone to be desensitized in longer duration treatment, with 25 µM of A-MG resulting in about 20% cell viability. Ascorbic acid-reduced AuNPs were found to be spherical with a size of 170 nm, zeta potential of -36 mV, and polydispersity index of about 17%. NaBH4-reduced AgNPs were also characterized to have irregular shapes at around 680 nm in size and a zeta potential of -21 mV. AgNPs and AuNPs were less potent against drug-resistant breast cancer cells. In MCF-7 cells, ascorbic acid-reduced AgNPs and NaBH4-reduced AuNPs caused 50% and 25% cell death using 10 µM, respectively. GO was observed to be toxic to both MCF-7 and MDA-MB-231, with viabil…
date: 2024-06-04
author list: authors
type: EPrint
type: ThesisEPrint
is part of: repository
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has document: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Other)
subject: RS Pharmacy and materia medica

Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
type: Document
has file: Final Hardbound Thesis.pdf
has part: Final Hardbound Thesis.pdf

Sunway University
type: Organization

School of Medical and Life Sciences, Sunway University
type: Organization

Jason Darmadi
type: Person
given name: Jason
family name: Darmadi

Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Other)
type: Document
is version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
is volatile version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
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Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Other)
type: Document
is version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
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Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Other)
type: Document
is version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
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Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Other)
type: Document
is version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
is volatile version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
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Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Other)
type: Document
is version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
is volatile version of: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells (Text)
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primary topic: Screening of synthesized nanoparticle and antineoplastics cytotoxicity against drug resistant breast cancer cells

RS Pharmacy and materia medica
type: Concept