In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2

Tan, Yi Jiun * and Tan, Yee Seng * and Yeo, Chien Ing * and Chew, Jactty * and Tiekink, Edward R. T. * (2019) In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {Cy3PAg(S2CNRR′)}2. Journal of Inorganic Biochemistry, 192. pp. 107-118. ISSN 0162-0134

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Official URL: http://doi.org/10.1016/j.jinorgbio.2018.12.017

Abstract

Four binuclear phosphanesilver(I) dithiocarbamates, {cyclohexyl3PAg(S2CNRR′)}2 for R = R′ = Et (1), CH2CH2 (2), CH2CH2OH (3) and R = Me, R′ = CH2CH2OH (4) have been synthesised and characterised by spectroscopy and crystallography, and feature tri-connective, μ2-bridging dithiocarbamate ligands and distorted tetrahedral geometries based on PS3 donor sets. The compounds were evaluated for anti-bacterial activity against a total of 12 clinically important pathogens. Based on minimum inhibitory concentration (MIC) and cell viability tests (human embryonic kidney cells, HEK 293), 1–4 are specifically active against Gram-positive bacteria while demonstrating low toxicity; 3 and 4 are active against methicillin resistant S. aureus (MRSA). Across the series, 4 was most effective and was more active than the standard anti-biotic chloramphenicol. Time kill assays reveal 1–4 to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Compound 4 demonstrates rapid (within 2 h) bactericidal activity at 1 and 2 × MIC to reach a maximum decrease of 5.2 log10 CFU/mL against S. aureus (MRSA).

Item Type: Article
Uncontrolled Keywords: Phosphanesilver(I) compounds; Dithiocarbamate; Thiolate; Anti-microbial; Time kill assay
Subjects: Q Science > QD Chemistry
Divisions: Sunway University > School of Science and Technology > Dept. Biological Sciences
Sunway University > School of Science and Technology > Research Centre for Crystalline Materials
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 14 Jan 2019 08:37
Last Modified: 02 May 2019 07:00
URI: http://eprints.sunway.edu.my/id/eprint/989

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