Optimisation of process parameters using D-optimal for enzymatic synthesis of polycaprolactone

Pakalapati, Harshini and Balaji, Anand B. and Senthil, K. Arumugasamy and Khalid, Mohammad * (2017) Optimisation of process parameters using D-optimal for enzymatic synthesis of polycaprolactone. Polymer Bulletin. ISSN 0170-0839

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Abstract

This work emphasizes on reactor scale synthesis of polycaprolactone using e-caprolactone as monomer and Candida antarctica lipase B enzyme as catalyst. The bio-polymerization was performed in 2 L thermostatic reactor by the conventional method with constant stirring. Optimisation of process parameters such as reactor temperature, reaction time, and mixing speed was carried out using response surface methodology based on D-optimal design. Molecular weight of the bio-polymer was chosen as the response for optimization, which is later characterised by gel permeation chromatography. The results show good agreement between predicted values and actual values obtained through the experiments.

Item Type: Article
Uncontrolled Keywords: Scale up; Polycaprolactone; Enzymatic polymerisation; D-optimal design
Subjects: Q Science > Q Science (General)
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Research Centre for Nano-Materials and Energy Technology
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 10 Dec 2018 09:22
Last Modified: 25 Apr 2019 07:46
URI: http://eprints.sunway.edu.my/id/eprint/984

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