PNMA family: Protein interaction network and cell signalling pathways implicated in cancer and apoptosis

Pang, Siew Wai * and Lahiri, Chandrajit * and Poh, Chit Laa * and Tan, Kuan Onn * (2018) PNMA family: Protein interaction network and cell signalling pathways implicated in cancer and apoptosis. Cellular Signalling, 45. pp. 54-62. ISSN 08986568

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Paraneoplastic Ma Family (PNMA) comprises a growing number of family members which share relatively conserved protein sequences encoded by the human genome and is localized to several human chromosomes, including the X-chromosome. Based on sequence analysis, PNMA family members share sequence homology to the Gag protein of LTR retrotransposon, and several family members with aberrant protein expressions have been reported to be closely associated with the human Paraneoplastic Disorder (PND). In addition, gene mutations of specific members of PNMA family are known to be associated with human mental retardation or 3-M syndrome consisting of restrictive post-natal growth or dwarfism, and development of skeletal abnormalities. Other than sequence homology, the physiological function of many members in this family remains unclear. However, several members of this family have been characterized, including cell signalling events mediated by these proteins that are associated with apoptosis, and cancer in different cell types. Furthermore, while certain PNMA family members show restricted gene expression in the human brain and testis, other PNMA family members exhibit broader gene expression or preferential and selective protein interaction profiles, suggesting functional divergence within the family. Functional analysis of some members of this family have identified protein domains that are required for subcellular localization, protein-protein interactions, and cell signalling events which are the focus of this review paper.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Dept. Biological Sciences moved to SMLS wef 2021
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre of Biomedical Physics [wef 2021 changed to Research Centre for Applied Physics and Radiation Technologies and moved to SET ]
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 18 Sep 2018 09:27
Last Modified: 23 Jan 2020 02:31

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