A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines

Lim, Felicia Phei Lin and Tan, Lin Yuing and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2018) A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines. RSC Advances, 8 (38). pp. 21495-21504. ISSN 2046-2069

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Official URL: http://doi.org/10.1039/c8ra03703e

Abstract

A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a] [1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Sunway University > School of Science and Technology > Research Centre for Crystalline Materials
Depositing User: Dr Janaki Sinnasamy
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Date Deposited: 18 Jun 2018 03:59
Last Modified: 22 Apr 2019 05:50
URI: http://eprints.sunway.edu.my/id/eprint/842

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