Racemic mefloquinium chlorodifluoroacetate: Crystal structure and Hirshfeld surface analysis

Wardell, James L. and Wardell, Solange M. S. V. and Jotani, Mukesh M. and Tiekink, Edward R. T. * (2018) Racemic mefloquinium chlorodifluoroacetate: Crystal structure and Hirshfeld surface analysis. Acta Crystallographica Section E Crystallographic Communications, 74 (7). pp. 895-900. ISSN 2056-9890

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Official URL: http://doi.org/10.1107/S2056989018007703

Abstract

In the racemic title molecular salt, C17H17F6N2O+.C2ClF2O3 -(systematic name:2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium chlorodifluoroacetate), the cation, which is protonated at the piperidine N atom, has the shape of the letter, L, with the piperidin-1-ium group being approximately orthogonal to the quinolinyl residue [the Cq—Cm—Cm–Na (q = quinolinyl; m = methine; a = ammonium) torsion angle is 177.79 (18)⁰]. An intramolecular, charge-assisted ammonium-N—H...O(hydroxyl) hydrogen bond ensures the hydroxy-O and ammonium-N atoms lie to the same side of the molecule [Oh—Cm—Cm—Na (h = hydroxyl) = -59.7 (2)⁰]. In the crystal, charge-assisted hydroxyl-O—H...O-(carboxylate) and ammonium-N+—H...O-(carboxylate) hydrogen bonds generate a supramolecular chain along [010]; the chain is consolidated by C—H...O interactions. Links between chains to form supramolecular layers are of the type C—Cl...π(quinolinyl-C6) and the layers thus formed stack along the a-axis direction without directional interactions between them. The analysis of the calculated Hirshfeld surface points to the dominance of F...H contacts to the surface (40.8%) with significant contributions from F...F (10.5%) and C...F (7.0%) contacts.

Item Type: Article
Uncontrolled Keywords: crystal structure; Mefloquine; salt; hydrogen bonding; Hirshfeld surface analysis.
Subjects: Q Science > QD Chemistry
Divisions: Sunway University > School of Science and Technology > Research Centre for Crystalline Materials
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 14 Jun 2018 03:19
Last Modified: 22 Apr 2019 05:51
URI: http://eprints.sunway.edu.my/id/eprint/836

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