Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers

Teow, Sin Yeang * and Liew, Kitson and Khoo, Alan Soo Beng and Peh, Suat Cheng * (2017) Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers. International Journal of Biological Sciences, 13 (10). pp. 1276-1286. ISSN 1449-2288

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Abstract

Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers. Interestingly, accumulating evidences showed that exosomes derived from tumour viruses or oncoviruses, exacerbate virus-associated cancers by remodelling the tumour microenvironment. In this review, we summarize the contributing factors of Epstein-Barr virus (EBV) products-containing exosomes in viral pathogenesis and their potential implications in EBV-driven malignancies. Understanding the biological role of these exosomes in the disease would undoubtedly boost the development of a more comprehensive strategy to combat EBV-associated cancers and to better predict the therapeutic outcomes. Furthermore, we also highlight the potentials and challenges of EBV products-containing exosomes being employed as diagnostic markers and therapeutic targets for EBV-related cancers. Since these aspects are rather underexplored, we attempt to underline interesting areas that warrant further investigations in the future.

Item Type: Article
Uncontrolled Keywords: Exosome; Epstein-Barr virus; EBV-associated cancer; LMP; nasopharyngeal carcinoma
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Others > Non Sunway Academics
Sunway University > School of Healthcare and Medical Sciences
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 04 Jun 2018 02:15
Last Modified: 03 Jun 2019 02:31
URI: http://eprints.sunway.edu.my/id/eprint/832

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