A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates:selective synthesis of substituted 5-aza-9-deaza-adenines

Lim, Felicia Phei Lin and Halcovitch, Nathan R. and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2018) A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates:selective synthesis of substituted 5-aza-9-deaza-adenines. Tetrahedron, 74 (15). pp. 1868-1879. ISSN 0040-4020

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Abstract

annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot,multicomponent, microwave-assisted approach. The products were obtained in good yields and high purity. This catalyst-free method was demonstrated to be scalable and highly reproducible in different microwave reactors. Some structural features of the prepared compounds were studied in details using dynamic NMR spectroscopy and X-ray crystallography.

Item Type: Article
Uncontrolled Keywords: Pyrazole; Purine isostere; Multicomponent reaction; Pyrazolo[1,5-a][1,3,5]triazine; Dynamic NMR spectroscopy
Subjects: Q Science > QD Chemistry
Divisions: Others > Non Sunway Academics
Depositing User: Dr Janaki Sinnasamy
Related URLs:
Date Deposited: 06 Apr 2018 02:53
Last Modified: 22 Apr 2019 05:51
URI: http://eprints.sunway.edu.my/id/eprint/790

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