Crystallographic, DFT and docking (cathepsin B) studies on an organotellurium(IV) compound

Caracelli, Ignez and Zukerman-Schpector, Julio and Madureira, Lucas Sousa and Maganhi, Stella H. and Stefani, Hélio A. and Guadagnin, Rafael C. and Tiekink, Edward R. T. * (2016) Crystallographic, DFT and docking (cathepsin B) studies on an organotellurium(IV) compound. Zeitschrift für Kristallographie - Crystalline Materials, 231 (6). pp. 321-328. ISSN 2194-4946

Z. Kristallogr. 2016 231 321.pdf - Accepted Version

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Some biologically active organotellurium compounds exhibit inhibitory potency against cathepsin B. In this study, an alkyl derivative, viz. [CH3(CH2)2C(I)=C(H)](nBu)TeI2, 1, has been structurally characterised by X-ray crystallography and shown to be coordinated within a C2I2 donor set. When the stereochemically active lone pair of electrons is taken into account, a distorted trigonal bipyramidal geometry results with the iodide atoms in axial positions. Both intra- and inter-molecular Te···I interactions are also noted. If all interactions are considered, the coordination geometry is based on a Ψ-pentagonal bipyramidal geometry. An unusual feature of the structure is the curving of the functionalised C5 chain. This feature has been explored by DFT methods and shown to arise as a result of close C–H···I interactions. A docking study (cathepsin B) was performed to understand the inhibition mechanism and to compare the new results with previous observations. Notably, 1 has the same pose exhibited by analogous biologically active compounds with aryl groups. Thus, the present study suggests that (alkyl)2TeX2 compounds should also be evaluated for biological activity.

Item Type: Article
Additional Information: First & 4th authors are with Universidade Federal de São Carlos, BioMat, Departamento de Física; 2nd & 3rd authors are with Universidade Federal de São Carlos, Laboratório de Cristalografia; 5th author is with Universidade de São Paulo, Departamento de Farmácia; 6th author is with Universidade Federal de São Paulo, Instituto e Ciências Ambientais; 7th author is with Sunway University, Centre for Crystalline Materials, Faculty of Science and Technology
Uncontrolled Keywords: crystal structure analysis; DFT; docking; organotellurium; X-ray diffraction
Subjects: Q Science > QD Chemistry
Divisions: Others > Non Sunway Academics
Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Research Centre for Crystalline Materials moved to SMLS wef 2021
Depositing User: Ms. Molly Chuah
Related URLs:
Date Deposited: 31 Oct 2017 09:13
Last Modified: 07 Oct 2020 09:58

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