New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases

Low, May Lee and Maigre, Laure and Mohamed, Ibrahim Mohamed Tahir and Tiekink, Edward R. T. * and Dorlet, Pierre and Guillot, Régis and Ravoof, Thahira Begum S. A. and Rozita Rosli, and Pagès, Jean-Marie and Policar, Clotilde and Delsuc, Nicolas and Crouse, Karen A. (2016) New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases. European Journal of Medicinal Chemistry, 120. pp. 1-12. ISSN 02235234

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2016.04.027

Abstract

Copper (II) complexes synthesized from the products of condensation of S-methyl- and S-benzyldithiocarbazate with 2,5-hexanedione (SMHDH2 and SBHDH2 respectively) have been characterized using various physicochemical (elemental analysis, molar conductivity, magnetic susceptibility) and spectroscopic (infrared, electronic) methods. The structures of SMHDH2, its copper (II) complex, CuSMHD, and the related CuSBHD complex as well as a pyrrole byproduct, SBPY, have been determined by single crystal X-ray diffraction. In order to provide more insight into the behaviour of the complexes in solution, electron paramagnetic resonance (EPR) and electrochemical experiments were performed. Antibacterial activity and cytotoxicity were evaluated. The compounds, dissolved in 0.5% and 5% DMSO, showed a wide range of antibacterial activity against 10 strains of Gram-positive and Gram-negative bacteria. Investigations of the effects of efflux pumps and membrane penetration on antibacterial activity are reported herein. Antiproliferation activity was observed to be enhanced by complexation with copper. Preliminary screening showed Cu complexes are strongly active against human breast adenocarcinoma cancer cell lines MDA-MB-231 and MCF-7.

Item Type: Article
Additional Information: 4th author, Edward Tiekink, is with Research Centre for Crystalline Materials, Faculty of Science and Technology, Sunway University
Uncontrolled Keywords: dithiocarbazate; schiff base; macroacyclic ligand; tetradendate ligand; nnss ligand; copper complexes; bioactivity; mda-mb-231; mcf-7; gram-positive; gram-negative dithiocarbazate; schiff base; macroacyclic ligand; tetradendate ligand; nnss ligand; copper complexes; bioactivity; mda-mb-231; mcf-7; gram-positive; gram-negative
Subjects: Q Science > QD Chemistry
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Research Centre for Crystalline Materials
Depositing User: Ms. Molly Chuah
Related URLs:
Date Deposited: 31 Oct 2017 06:31
Last Modified: 13 May 2019 09:14
URI: http://eprints.sunway.edu.my/id/eprint/649

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