In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

Chen, Bao-Jing and Nazzatush Shimar Jamaludin, and Khoo, Chai-Hoon and See, Tian-Hong and Sim, Jiun-Horng and Cheah, Yoke-Kqueen and Siti Nadiah Abdul Halim, and Seng, Hoi-Ling * and Tiekink, Edward R. T. * (2016) In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates. Journal of Inorganic Biochemistry, 163. pp. 68-80. ISSN 01620134

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Official URL: http://dx.doi.org/10.1016/j.jinorgbio.2016.08.002

Abstract

Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimuminhibitory concentration (MIC) scores, compounds 1 and 2 were shown tobe specifically potent against Grampositive bacteriawhereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3were bactericidal againstMRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria.

Item Type: Article
Additional Information: First, 3rd, 4th, 5th, and 6th authors are with Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia; 2nd and 7th authors are with Department of Chemistry, University of Malaya; 8th author is with Department of Biological Sciences, Faculty of Science and Technology, Sunway University; 9th author is with Research Centre for Crystalline Materials, Faculty of Science and Technology, Sunway University
Uncontrolled Keywords: phosphanegold(I) compounds; dithiocarbamate; thiolate antimicrobial; time kill assay
Subjects: Q Science > QD Chemistry
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Dept. Biological Sciences
Sunway University > School of Science and Technology > Research Centre for Crystalline Materials
Depositing User: Ms. Molly Chuah
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Date Deposited: 24 Oct 2017 07:54
Last Modified: 22 Apr 2019 06:29
URI: http://eprints.sunway.edu.my/id/eprint/614

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