Antibacterial action of curcumin against Staphylococcus aureus: A brief review

Teow, Sin Yeang * and Liew, Kitson and Syed A. Ali, and Khoo, Alan Soo Beng and Peh, Suat Cheng * (2016) Antibacterial action of curcumin against Staphylococcus aureus: A brief review. Journal of Tropical Medicine, 2016. pp. 1-10. ISSN 1687-9686

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Abstract

Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family) or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against Staphylococcus aureus (S. aureus). As demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future. However, there are several noteworthy challenges in the development of curcumin as a medicine. S. aureus infections, particularly those caused by themultidrug-resistant strains, have emerged as a global health issue and urgent action is needed. This review focuses on the antibacterial activities of curcumin against both methicillin-sensitive S. aureus (MSSA) and methicillin resistant S. aureus (MRSA). We also attempt to highlight the potential challenges in the effort of developing curcumin into a therapeutic antibacterial agent.

Item Type: Article
Additional Information: First and 5th authors are with Sunway Institute for Healthcare Development (SIHD), Sunway University; 2nd author is with Molecular Pathology Unit, Cancer Research Centre (CaRC), Institute for Medical Research (IMR); 3rd author is with the Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM); 4th author is with Institute for Research, Development and Innovation, International Medical University
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Others > Non Sunway Academics
Sunway University > Research Centres > Sunway Institute for Healthcare Development
Depositing User: Dr Janaki Sinnasamy
Date Deposited: 30 Nov 2016 02:16
Last Modified: 02 Nov 2017 09:05
URI: http://eprints.sunway.edu.my/id/eprint/426

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