The development of drugs against Acanthamoeba infections

Siddiqui, Ruqaiyyah Bano * and Aqeel, Yousuf and Khan, Naveed Ahmed * (2016) The development of drugs against Acanthamoeba infections. Antimicrobial Agents and Chemotherapy, 60 (11). pp. 6441-6450. ISSN 0066-4804

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Official URL: doi:10.1128/AAC.00686-16.

Abstract

For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate of development of novel antiacanthamoebic chemotherapies of translational value and the lack of interest of the pharmaceutical industry in developing such chemotherapies have been disappointing. On the other hand, the market for contact lenses/contact lens disinfectants is a multi-billion-dollar industry and has been successful and profitable. A better understanding of drugs, their targets, and mechanisms of action will facilitate the development of more-effective chemotherapies. Here, we review the progress toward phenotypic drug discovery, emphasizing the shortcomings of useable therapies.

Item Type: Article
Additional Information: 2nd author is with Department of Molecular and Cell Biology, School of Medicine, Boston University
Subjects: Q Science > QR Microbiology
Divisions: Sunway University > School of Science and Technology > Dept. Biological Sciences
Others > Non Sunway Academics
Depositing User: Dr Janaki Sinnasamy
Date Deposited: 13 Oct 2016 01:00
Last Modified: 19 Jan 2017 09:52
URI: http://eprints.sunway.edu.my/id/eprint/411

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