Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review

Almas, Talal and Rehman, Sarah and Mansour, Eyad and Khedro, Tarek and Alansari, Ali and Jahanzeb, Malik * and Alshareef, Norah and Nagarajan, Vikneswaran Raj and Al-Awaid, Abdulla Hussain and Alsufyani, Reema and Alsufyani, Majid and Rifai, Ali and Ahlam, Alzahrani and Dhineswaran, Raj Nagarajan * and Abdullatif, Tala and Gunasaegaram, Varman and Alzadjali, Enaam and Subramanian, Arthi and Rahman, Abida and Sattar, Yasar and Galo, Jason and Virk, Hafeez Ul Hassan and Alraies, M. Chadi (2022) Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review. Biomedicine and Pharmacotherapy, 149. ISSN 0753-3322

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Official URL: https://doi.org/10.1016/j.biopha.2022.112843

Abstract

The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology.

Item Type: Article
Uncontrolled Keywords: Coronavirus 2019 (COVID-19); SARS-CoV-2; COVID-19 mRNA vaccine; COVID-19 myocarditis; COVID-19 perimyocarditis; Takotsubo syndrome;
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences
Depositing User: Ms Yong Yee Chan
Date Deposited: 13 Aug 2024 23:44
Last Modified: 13 Aug 2024 23:44
URI: http://eprints.sunway.edu.my/id/eprint/3130

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