A proposed cascade of vascular events leading to granulomatous amoebic encephalitis

Baig, Abdul Mannan and Khan, Naveed Ahmed * (2015) A proposed cascade of vascular events leading to granulomatous amoebic encephalitis. Microbial Pathogenesis, 88. pp. 48-51. ISSN 0882-4010

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a significant latent period of several months before the appearance of clinical manifestations is puzzling. Based on reported cases, here we propose pathogenetic mechanisms that explain the above described latency of the disease.

Item Type: Article
Additional Information: First author is with Department of Biological and Biomedical Sciences, Aga Khan University, Pakistan; 2nd author is with Department of Biological Sciences, Faculty of Science and Technology, Sunway University, Malaysia
Uncontrolled Keywords: Protists; Acanthamoeba; Balamuthia mandrillaris; Granulomatous amoebic encephalitis
Subjects: Q Science > QR Microbiology
Divisions: Sunway University > School of Science and Technology > Dept. Biological Sciences
Depositing User: Ms. Molly Chuah
Date Deposited: 28 Mar 2016 06:59
Last Modified: 28 Mar 2016 06:59
URI: http://eprints.sunway.edu.my/id/eprint/313

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