High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: A systematic review and meta-analysis

Nabil Izzaatie, Mohamad Safiai and Nur Afiqah, Mohamad and Hamidon, Basri and Liyana Najwa, Inche Mat and Hoo, Fan Kee and Anna Misyail, Abdul Rashid and Abdul Hanif Khan, Yusof Khan and Loh, Wei Chao and Janudin, Baharin and Fernandez, Aaron and Intan Nureslyna, Samsudi and Mohd Hazmi, Mohamed and Ching, Siew Mooi * and Lee, Kai Wei and Ramachandran, Vasudevan and Pozo-Rosich, Patricia and Wan Aliaa, Wan Sulaiman (2022) High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: A systematic review and meta-analysis. Cephalalgia, 42 (10). pp. 1071-1085. ISSN 1468-2982

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Official URL: https://doi.org/10.1177/03331024221092423

Abstract

Objective: To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as a migraine prevention by conducting a systematic review and meta-analysis. Background: The efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as preventive migraine treatment remains debatable. Methods: PubMed, Scopus, CINAHL, CENTRAL, and BioMed Central databases were searched from their inception until December 2020. Randomised trials comparing high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex with sham for migraine prevention were included. The risk of bias was assessed using the Cochrane guidelines. Headache days, pain intensity, acute medication intake, and disability were extracted as study outcomes and the mean difference with a random-effects model was used to determine the effect size. Results: Meta-analysis revealed that high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex significantly reduced acute medication intake (Mean Difference = 9.78, p = 0.02, 95%CI: 1.60, 17.96, p = 0.02) and functional disability (Mean Difference = 8.00, p < 0.05, 95%CI: 4.21, 11.79). However, no differences were found in headache days and pain intensity reduction, although there was a slight trend favouring high-frequency repetitive transcranial magnetic stimulation. Conclusion: High-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex may be effective in reducing acute medication intake and disability. However, more studies are needed to strengthen this preliminary evidence.

Item Type: Article
Uncontrolled Keywords: Migraine prevention; dorsolateral prefrontal cortex (DLPFC); high-frequency repetitive transcranial magnetic stimulation (HF-rTMS); meta-analysis; systematic review.
Subjects: R Medicine > RC Internal medicine
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences
Depositing User: Ms Yong Yee Chan
Date Deposited: 13 Aug 2024 01:06
Last Modified: 13 Aug 2024 01:06
URI: http://eprints.sunway.edu.my/id/eprint/3099

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