Tan, Ee Wern * and Noraini, Abd-Aziz * and Poh, Chit Laa * and Tan, Kuan Onn * (2022) Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy. Pathogens and Global Health, 11 (10). ISSN 2047-7724
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Abstract
Cancer is among the major leading causes of mortality globally, and chemotherapy is currently one of the most effective cancer therapies. Unfortunately, chemotherapy is invariably accompanied by dose-dependent cytotoxic side effects. Recently, genetically engineered adenoviruses emerged as an alternative gene therapy approach targeting cancers. This review focuses on the characteristics of genetically modified adenovirus and oncology clinical studies using adenovirus-mediated gene therapy strategies. In addition, modulation of the tumor biology and the tumor microenvironment as well as the immunological responses associated with adenovirus-mediate cancer therapy are discussed.
| Item Type: | Article |
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| Uncontrolled Keywords: | oncolytic adenovirus; immune system; tumor microenvironment (TME); cancer therapy |
| Subjects: | Q Science > QR Microbiology R Medicine > RC Internal medicine |
| Divisions: | Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Microbiome Centre [formerly Centre for Virus and Vaccine Research until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 12 Aug 2024 08:37 |
| Last Modified: | 12 Aug 2024 08:37 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3077 |
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