Yong, Chean Yeah and Liew, Winnie Pui Pui and Ong, Hui Kian and Poh, Chit Laa * (2022) Development of virus-like particles-based vaccines against. Biotechnology Progress, 38 (6). ISSN 1520-6033
Full text not available from this repository.Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the most impactful coronaviruses in human history, especially the latter, which brings revolutionary changes to human vaccinology. Due to its high infectivity, the virus spreads rapidly throughout the world and was declared a pandemic in March 2020. A vaccine would normally take more than 10 years to be developed. As such, there is no vaccine available for SARS-CoV and MERS-CoV. Currently, 10 vaccines have been approved for emergency use by World Health Organization (WHO) against SARS-CoV-2. Virus-like particle (VLP)s are nanoparticles resembling the native virus but devoid of the viral genome. Due to their self-adjuvanting properties, VLPs have been explored extensively for vaccine development. However, none of the approved vaccines against SARS-CoV-2 was based on VLP and only 4% of the vaccine candidates in clinical trials were based on VLPs. In the current review, we focused on discussing the major advances in the development of VLP-based vaccine candidates against the SARS-CoV, MERS-CoV, and SARS-CoV-2, including those in clinical and pre-clinical studies, to give a comprehensive overview of the VLP-based vaccines against the coronaviruses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Middle East respiratory syndrome coronavirus (MERS-CoV); severe acute respiratory syndrome coronavirus (SARS-CoV); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); vaccines; virus-like particle (VLP). |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Microbiome Centre [formerly Centre for Virus and Vaccine Research until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 12 Aug 2024 08:07 |
| Last Modified: | 12 Aug 2024 08:07 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3073 |
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