Lum, Pei Teng and Mahendran, Sekar and Gan, Siew Hua and Jeyabalan, Srikanth and Bonam, Srinivasa Reddy and Nur Najihah, Izzati Mat Rani and Ku-Marina, Ku-Mahdzir and Seow, Lay Jing and Wu, Yuan Seng * and Vetriselvan, Subramaniyan and Fuloria, Neeraj Kumar and Fuloria, Shivkanya (2022) Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review. Saudi Journal of Biological Sciences, 29 (3). pp. 1530-1542. ISSN 1319-562X
Full text not available from this repository. (Request a copy)Abstract
There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | drug delivery; in-silico; kidney disorders; Mangifera indica; Mangiferin; reno-protective. |
| Subjects: | Q Science > QK Botany R Medicine > RC Internal medicine R Medicine > RS Pharmacy and materia medica |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Microbiome Centre [formerly Centre for Virus and Vaccine Research until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 06 Aug 2024 07:54 |
| Last Modified: | 06 Aug 2024 07:54 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3027 |
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