Jing, XiBo and Sarker, Md. Moklesur Rahman and Gifari, Md. Abu Jar and Maruf, Md. Rifat Alam and Alam, Safaet and Khan, Farzana and Soma, Mahfuza Afroz and Md. Sanower, Hossain and Long, Chiau Ming * and Ahmad, Shihab Uddin and Hasan, Raquibul (2022) Improvement of lipid profile and hepatic oxidative stress in high-fat-diet- induced hyperlipidemic Swiss albino rats by Piper betle juice: evidences from in vivo and in silico studies. Cellular and Molecular Biology, 68 (9). pp. 1-13. ISSN 1098-5549
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Piper betle L. leaves are very popular and traditionally used to chew with betel nut in many Asian countries. In this study, P. betle leaves juice (PBJ) was subjected to evaluation for its antihyperlipidemic activity in the high-fat-diet-induced hyperlipidemic rats model. Swiss albino rats were allowed to high-fat- diet for one month, followed by concurrent administration of PBJ for another month. The rats were then sacrificed and collected blood, tissues and organs. Pharmacokinetic, toxicological studies and molecular docking studies were performed using SwissADME, admetSAR and schrodinger suit-2017. Our investigation showed a promising effect of PBJ on body weight, lipid profile, oxidative and antioxidative enzymes, and the principle enzyme responsible for the synthesis of cholesterol. PBJ at 0.5 - 3.0 mL/rat significantly reduced body weight of hyperlipidemic rats compared to control. PBJ at the doses of 1.0, 1.5, 2.0, and 3.0 mL/rat significantly (p<0.05, p<0.01, p<0.001) improved the levels of TC, LDL-c, TG, HDL-c and VLDL-c. Similarly, PBJ doses starting from 1.0 mL/rat to 3.0 mL/rat reduced the oxidative biomarkers AST, ALT, ALP, and creatinine. The level of HMG-CoA was significantly reduced by PBJ doses 1.5, 2, and 3 ml/rat. A number of compounds have been found to have good pharmacokinetic profile and safety and 4-coumaroylquinic acid exerted the best docking score among them. Thus our findings clearly demonstrated the potential lipid-lowering activities of PBJ both in vivo and in silico studies. PBJ can be a good candidate for the development of antihyperlipidemic medication or as an alternative medicine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | hyperlipidemia; piper betel; piper betle L; betel leaves; functional food; nutraceutical; high fat diet; oxidative stress; Swiss albino rats; in silico approaches; drug likeliness; molecular docking; in vivo study |
| Subjects: | Q Science > QK Botany Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 06 Aug 2024 02:35 |
| Last Modified: | 06 Aug 2024 02:35 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3006 |
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