Su, Kar Yan and Koh Kok, Jie Yi and Chua, Yie Wei and Ong, Shearn Dior and Ser, Hooi Leng * and Priyia, Pusparajah and Saw, Pui San and Goh, Bey Hing * and Lee, Wai Leng (2022) Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers. Expert Review of Molecular Diagnostics, 22 (12). pp. 1057-1062. ISSN 1744-8352
Full text not available from this repository. (Request a copy)Abstract
Introduction: Extracellular vesicles (EVs) are spherical membrane-derived lipid bilayers released by cells. The human microbiota consists of trillions of microorganisms, with bacteria being the largest group secreting microbial EVs. The discovery of bacterial EVs (BEVs) has garnered interest among researchers as potential diagnostic markers, given that the microbiota is known to be associated with various diseases and EVs carry important macromolecular cargo for intercellular interaction. Areas covered: The differential bacterial composition identified from BEVs isolated from biofluids between patients and healthy controls may be valuable for detecting diseases. Therefore, BEVs may serve as novel diagnostic markers. Literature search on PubMed and Google Scholar databases was conducted. In this special report, we outline the commonly used approach for investigating BEVs in biofluids, the 16S ribosomal RNA gene sequencing of V3-V4 hypervariable regions, and the recent studies exploring the potential of BEVs as biomarkers for various diseases. Expert opinion: The emerging field of BEVs offers new possibilities for the diagnosis of various types of diseases, although there remain issues that need to be resolved in this research area to implement BEVs in clinical applications. Hence, it is important for future studies to take these challenges into consideration when investigating the diagnostic value of BEVs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | bacterial extracellular vesicles; biofluids; biomarkers; diagnosis; gene sequencing; microbiota. |
| Subjects: | Q Science > QH Natural history Q Science > QR Microbiology R Medicine > R Medicine (General) |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 06 Aug 2024 01:49 |
| Last Modified: | 06 Aug 2024 01:49 |
| URI: | http://eprints.sunway.edu.my/id/eprint/3003 |
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