Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms

Ee, Jia Wer and Appalaraju, Velaga and Rhanye, Mac Guad and Vetriselvan, Subramaniyan and Fuloria, Neeraj Kumar and Fuloria, Shivkanya and Choy, Ker Woon and Wu, Yuan Seng * (2022) Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms. Sains Malaysiana, 51 (1). pp. 199-208. ISSN 1749-1758

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Official URL: https://doi.org/10.17576/jsm-2022-5101-16

Abstract

Medicinal plants with less side effects are paramount important for humankind to cure various ailments as compared to newly developed allopathic medicines. Synsepalum dulcificum Daniell (Sapotaceae), is well known as miracle fruits due to its distinctive taste-modifying property. This review aimed to discuss its recent reported pharmacological properties and associated molecular mechanisms as a novel phytotherapy agent. In addition, background, phytochemical analysis and toxicological studies were also discussed as the foundation and added values for this review. It was discovered that S. dulcificum is endowed with various classes of phytochemicals, such as flavonoids, tannins, alkaloids and saponins. This review ravelled that S. dulcificum is a potent medicinal plant associated with antioxidant, antidiabetic, antimicrobial, anticancer, anti-hyperuricemic, hepatoprotective, anti-hyperlipidaemic, and anticonvulsant activities, with less toxicity shown. Future research may explore further the corresponding phytochemicals, associated molecular mechanisms, toxicological and pharmacokinetic profile before subjecting to clinical testing.

Item Type: Article
Uncontrolled Keywords: miracle fruit; molecular mechanism; phytotherapy agent; Synsepalum dulcificum; therapeutic activity;
Subjects: Q Science > QK Botany
R Medicine > RM Therapeutics. Pharmacology
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Microbiome Centre [formerly Centre for Virus and Vaccine Research until 2023]
Depositing User: Ms Yong Yee Chan
Related URLs:
Date Deposited: 04 Aug 2024 07:14
Last Modified: 04 Aug 2024 07:14
URI: http://eprints.sunway.edu.my/id/eprint/2984

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