Pana, Tiberiu A. and Kioh, Sheng Hui and Neal, Samuel R. and Tan, Maw Pin * and Sumaiyah, Mat and Moayyeri, Alireza and Luben, Robert N. and Wareham, Nicholas J. and Khaw, Kay Tee and Myint, Phyo K (2023) Body Fat Percentage and the Long-term Risk of Fractures. The EPIC-Norfolk Prospective Population Cohort Study. Maturitas, 168. pp. 71-77. ISSN 03785122
Full text not available from this repository.Abstract
Background This cohort study aimed to determine the association between body fat percentage (BF%), incident fractures and calcaneal broadband ultrasound attenuation (BUA). Methods Participants were drawn from the EPIC-Norfolk Prospective Population Cohort Study (median follow-up = 16.4 years). Cox models analysed the relationship between BF% and incident fractures (all and hip). Linear and restricted cubic spline (RCS) regressions modelled the relationship between BF% and BUA. Results 14,129 participants (56.2 % women) were included. There were 1283 and 537 incident all and hip fractures respectively. The participants had a mean (standard deviation) age of 61.5 (9.0) years for women and 62.9 (9.0) years for men. Amongst men, BF% was not associated with incident all fractures. While BF% < 23 % (median) was not associated with hip fractures, BF% > 23 % was associated with increased risk of hip fractures by up to 50 % (hazard ratio (95 % confidence interval) = 1.49 (1.06–2.12)). In women, BF% < 39 % (median) was associated with up to 32 % higher risk of all fractures (1.32 (1.13–1.44)), while BF% > 35 % was not associated with this outcome. Higher BF% was associated with lower risk of incident hip fractures in women. Higher BF% was associated with higher BUA amongst women. Higher BF% up to ~23 % was associated with higher BUA amongst men. Conclusions Higher BF% is associated with lower risk of fractures in women. While there was no association between BF% and all fractures in men, increasing BF% >23 % was associated with higher risk of hip fractures in men. This appears to be independent of estimated bone mineral density. Fracture prevention efforts need to consider wider physical, clinical, and environmental factors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Ageing; Fracture; Body composition; Osteoporosis; |
| Subjects: | Q Science > QH Natural history Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RC Internal medicine |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. of Medical Education [formerly Dept. of Allied Healthcare until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 23 Jul 2024 06:06 |
| Last Modified: | 23 Jul 2024 06:06 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2856 |
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