Siddiqui, Ruqaiyyah and Ong, Timonthy Yu Yee * and Maciver, Sutherland and Khan, Naveed Ahmed (2023) Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route? Therapeutic Delivery, 14 (8). pp. 485-490. ISSN 2041-6008
Full text not available from this repository.Abstract
Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adverse effects; amphotericin B; blood-brain barrier; brain-eating amoebae; CNS infection; free-living amoebae; intranasal route; Naegleria fowleri; novel therapeutic delivery; primary amoebic meningoencephalitis; |
| Subjects: | Q Science > QL Zoology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 16 Jul 2024 03:07 |
| Last Modified: | 16 Jul 2024 03:07 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2827 |
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