Ser, Hooi Leng * and Wong, Joshua You Jing * and Goh, Bey Hing * and Kavita, Reginald * and Raja Affendi, Raja Ali * (2023) Chronic urticaria and the gut microbiota: what is this 'long-distance' relationship? Gut, 72. ISSN 1468-3288
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Background Chronic urticaria is characterized by daily itchy wealing of the skin for more than six weeks, affecting roughly 0.5 – 2% of the global population. Although the precise causes of chronic urticaria are not usually known, it has been suggested that this condition may arise due to autoimmune disorders, allergies, infections, or medications. The gut microbiome plays an important role in immune regulation and its effects in many immune-mediated diseases have been reported. Consequently, this work investigates the distinctive gut microbiota changes in chronic urticaria and the potential of identifying biomarkers or therapeutic targets to facilitate disease diagnosis/treatment. Methods Searches were performed in four databases (PubMed, MEDLINE, EMBASE, ScienceDirect; database inception to 31st January 2023) using ‘hives’, ‘urticaria’, ‘gut microbiota’, and ‘gut microbiome’ as MeSH terms (following PRISMA guidelines). All titles and abstracts retrieved were screened based on the inclusion and exclusion criteria. Studies reporting gut microbiome data in relation to chronic urticaria were included in the current analysis but not those without gut microbiome data/with other interventions. Results Nine human studies on gut microbiota changes in chronic urticaria were selected from 29 papers using the inclusion and exclusion criteria (IDDF2023-ABS-0239 Figure 1). Six studies were conducted in China, while the remaining three studies were done in Iran and Turkey. All studies reported significant changes in gut microbiota, involving the predominant gut bacterial phylum such as Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria. Although results reported for these phyla were heterogenous, two studies indicated the potential diagnostic values of the selected genus including genus Lachnobacterium, Turicibacter, Lactobacillus, Romboutsia and Ruminococcus. Besides that, a study in 2021 examined the correlation between microbial markers, duration of chronic urticaria and patients’ quality of life. The team noted that the abundance of Enterobacteriaceae and Klebsiella positively correlated with the duration of the disease, while the abundance of Clostridium disporicum was positively correlated with the dermatology life quality index. Conclusions Altogether, these findings demonstrate the influence of gut health on chronic urticaria. Additional research into microbiome-based therapies like probiotics/symbiotics could help manage the condition long-term and understand the mechanics of communication between these two remote sites.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chronic urticaria; therapeutic; gut health; probiotics; symbiotics; microbiome-based therapies; gut microbiota |
| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RL Dermatology |
| Divisions: | Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > SMLS Admin Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Biofunctional Molecules Discovery Centre [formerly Research Centre for Crystalline Materials until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 12 Jul 2024 03:08 |
| Last Modified: | 12 Jul 2024 03:08 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2798 |
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