Looi, Chin King and Foong, Lian Chee and Chung, Felicia Fei Lei * and Khoo, Alan Soo Beng and Loo, Ee Mun and Leong, Chee Onn and Mai, Chun Wai (2023) Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer. Cell Biology and Toxicology, 39. pp. 2501-2526. ISSN 1573-6822
Full text not available from this repository. (Request a copy)Abstract
Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer that is highly associated with Epstein-Barr virus (EBV) infection. EBV acts as an epigenetic driver in NPC tumorigenesis, reprogramming the viral and host epigenomes to regulate viral latent gene expression, and creating an environment conducive to the malignant transformation of nasopharyngeal epithelial cells. Targeting epigenetic mechanisms in pre-clinical studies has been shown promise in eradicating tumours and overcoming immune resistance in some solid tumours. However, its efficacy in NPC remains inclusive due to the complex nature of this cancer. In this review, we provide an updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. We also explore the crosstalk between epigenetic mechanisms and immune evasion in NPC. Particularly, we discuss the potential roles of DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, we highlight the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes. Epigenetic drugs have the potential to modulate both epigenetic mediators and immune factors involved in NPC. However, further research is needed to fully comprehend the diverse range of epigenetic modifications in NPC. A deeper understanding of the crosstalk between epigenetic mechanisms and immune evasion during NPC progression is crucial for the development of more effective treatments for this challenging disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | epigenetics; Epstein-Barr virus; immune evasion; nasopharyngeal carcinoma; |
| Subjects: | Q Science > QH Natural history Q Science > QR Microbiology R Medicine > RF Otorhinolaryngology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 08 Jul 2024 02:13 |
| Last Modified: | 08 Jul 2024 02:13 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2751 |
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