Yong, Shin Jie * and Halim, Alice and Halim, Michael and Liu, Shiliang and Aljeldah, Mohammed and Shammari, Basim R Al and Alwarthan, Sara and Alhajri, Mashael and Alawfi, Abdulsalam and Alshengeti, Amer and Khamis, Faryal and Alsalman, Jameela and Alshukairi, Abeer N and Abukhamis, Nujoud A and Almaghrabi, Fatimah S and Almuthree, Souad A and Alsulaiman, Abdulrahman M and Alshehail, Bashayer M and Alfaraj, Amal H and Alhawaj, Shorouq A and Mohapatra, Ranjan K and Rabaan, Ali A (2023) Inflammatory and vascular biomarkers in post-COVID-19 syndrome: A systematic review and meta-analysis of over 20 biomarkers. Reviews in Medical Virology, 33 (2). ISSN 10991654
Full text not available from this repository.Abstract
Severe acute respiratory syndrome coronavirus 2 may inflict a post-viral condition known as post-COVID-19 syndrome (PCS) or long-COVID. Studies measuring levels of inflammatory and vascular biomarkers in blood, serum, or plasma of COVID-19 survivors with PCS versus non-PCS controls have produced mixed findings. Our review sought to meta-analyse those studies. A systematic literature search was performed across five databases until 25 June 2022, with an updated search on 1 November 2022. Data analyses were performed with Review Manager and R Studio statistical software. Twenty-four biomarkers from 23 studies were meta-analysed. Higher levels of C-reactive protein (Standardized mean difference (SMD) = 0.20; 95% CI: 0.02-0.39), D-dimer (SMD = 0.27; 95% CI: 0.09-0.46), lactate dehydrogenase (SMD = 0.30; 95% CI: 0.05-0.54), and leukocytes (SMD = 0.34; 95% CI: 0.02-0.66) were found in COVID-19 survivors with PCS than in those without PCS. After sensitivity analyses, lymphocytes (SMD = 0.30; 95% CI: 0.12-0.48) and interleukin-6 (SMD = 0.30; 95% CI: 0.12-0.49) were also significantly higher in PCS than non-PCS cases. No significant differences were noted in the remaining biomarkers investigated (e.g., ferritin, platelets, troponin, and fibrinogen). Subgroup analyses suggested the biomarker changes were mainly driven by PCS cases diagnosed via manifestation of organ abnormalities rather than symptomatic persistence, as well as PCS cases with duration of <6 than ≥6 months. In conclusion, our review pinpointed certain inflammatory and vascular biomarkers associated with PCS, which may shed light on potential new approaches to understanding, diagnosing, and treating PCS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SARS-CoV-2; biomarkers; inflammation; long-COVID; post-COVID-19 syndrome; vascular disorders; |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Dept. Biological Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 05 Jul 2024 03:13 |
| Last Modified: | 05 Jul 2024 03:13 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2738 |
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