Mostafa, Yusefi and Shameli, Kamyar and Soon, Michiele Lee Kiun * and Teow, Sin Yeang and Moeini, Hassan and Roshafima, Rasit Ali and Pooneh, Kia and Jie, Chia Jing and Nurul Hidayah, Abdullah (2023) Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment. International Journal of Biological Macromolecules, 233. ISSN 1879-0003
Full text not available from this repository.Abstract
Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe3O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated magnetic CNW for 5-fluorouracil carrier abbreviated as CH/MCNW/5FU. Fourier-transform infrared, X-Ray diffraction, and X-ray photoelectron spectroscopy analysis indicated successful fabrication and multifunctional properties of the CH/MCNW/5FU nanocomposites. In addition, CH/MCNW/5FU nanocomposites showed hydrodynamic diameter and zeta potential value of 181.31 ± 3.46 nm and +23 ± 1.8 mV, respectively. Based on images of transmission electron microscopy, magnetic CNW as reinforcement was coated with chitosan to obtain almost spherical CH/MCNW/5FU nanocomposites with an average diameter of 37.16 ± 3.08. The nanocomposites indicated desired saturation magnetization and thermal stability, high drug encapsulation efficiency, and pH-dependent swelling and drug release performance. CH/MCNW/5FU nanocomposites showed potent killing effects against colorectal cancer cells in both 2D monolayer and 3D spheroid models. These findings suggest CH/MCNW as a potential carrier for anticancer drugs with high tumour-penetrating capacity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | colorectal cancer; cytotoxicity assay; drug delivery systems; magnetic nanocomposites; polysaccharides; |
| Subjects: | Q Science > QR Microbiology R Medicine > RC Internal medicine T Technology > TP Chemical technology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Department of Medical Sciences |
| Depositing User: | Ms Yong Yee Chan |
| Date Deposited: | 04 Jul 2024 01:25 |
| Last Modified: | 04 Jul 2024 01:25 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2731 |
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