Noraini, Abd-Aziz * and Lee, Michelle Felicia * and Ong, Seng Kai * and Poh, Chit Laa * (2024) Antiviral activity of SP81 peptide against Enterovirus A71 (EV-A71). Virology, 589. ISSN 0042 6822
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The hand, food, and mouth disease (HFMD) is primarily caused by Enterovirus A71 (EV-A71). EV-A71 outbreaks in the Asia Pacific have been associated with severe neurological disease and high fatalities. Currently, there are no FDA-approved antivirals for the treatment of EV-A71 infections. In this study, the SP81 peptide, derived from the VP1 capsid protein of EV-A71 was shown to be a promising antiviral candidate for the treatment of EV-A71 infections. SP81 peptide was non-toxic to RD cells up to 45 μM, with a half-maximal cytotoxic concentration (CC50) of 90.32 μM. SP81 peptide exerted antiviral effects during the pre- and post-infection stages with 50% inhibitory concentrations (IC50) of 4.529 μM and 1.192 μM, respectively. Direct virus inactivation of EV-A71 by the SP81 peptide was also observed with an IC50 of 8.076 μM. Additionally, the SP81 peptide exhibited direct virus inactivation of EV-A71 at 95% upon the addition of the SP81 peptide within 5 min. This study showed that the SP81 peptide exhibited significant inhibition of EV-A71 and could serve as a promising antiviral agent for further clinical development against EV-A71 infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SP81; peptide; VP1; capsid protein; EV-A71; RD cells; virus inactivation; |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Centre for Virus and Vaccine Research moved to SMLS wef 2021 Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Dept. Biological Sciences moved to SMLS wef 2021 |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 20 May 2024 01:10 |
| Last Modified: | 20 May 2024 01:10 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2620 |
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