Polymorphism of HLA and Susceptibility of Breast Cancer

Aboulaghras, Sara and Khalid, Asaad and Makeen, Hafiz A and Alhazmi, Hassan A and Albratty, Mohammed and Mohan, Syam and Goh, Bey Hing * and Yeo, Chien Ing * and Tan, Yee Seng * and Bouyahya, Abdelhakim (2024) Polymorphism of HLA and Susceptibility of Breast Cancer. Frontiers in Bioscience-Landmark, 29 (2). ISSN 2768-6698

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Official URL: https://doi.org/10.31083/j.fbl2902055


Breast cancer (BC) is the second most common malignancy in the world. Numerous studies have demonstrated the association between human leukocyte antigen (HLA) and cancer. The occurrence and development of BC are closely linked to genetic factors. Human leukocyte antigens G and E (HLA-G and HLA-E) are non-classical major histocompatibility complex (MHC) class I molecules. These molecules play an important role in immune surveillance by inhibiting the cytotoxic and natural killer T cells responsible for immune escape. The expression of HLA-G and HLA-E has been associated with several diseases, including tumors. The HLA system plays a key role in the escape of tumor cells from immune surveillance. This review aims to determine the correlation between BC susceptibility and HLA markers specific HLA alleles such as HLA-B07, HLA-DRB111, HLA-DRB113, and HLA-DRB115 are associated with an increased risk of developing BC. Furthermore, HLA-G mutations have been attributed to an elevated likelihood of metastasis in BC patients. Understanding the complex associations between the HLA system and BC development is critical for developing novel cancer prevention, detection, and treatment strategies. This review emphasizes the importance of analyzing HLA polymorphisms in the management of BC patients, as well as the urgent need for further research in this area.

Item Type: Article
Uncontrolled Keywords: breast cancer; genetic polymorphism; prevention;
Subjects: Q Science > QH Natural history
R Medicine > RB Pathology
R Medicine > RC Internal medicine
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020]
Depositing User: Ms Yong Yee Chan
Related URLs:
Date Deposited: 16 May 2024 03:59
Last Modified: 16 May 2024 03:59
URI: http://eprints.sunway.edu.my/id/eprint/2614

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