A comprehensive review on ethnomedicinal uses, phytochemistry, toxicology, and pharmacological activities of Dittrichia viscosa (L.) Greuter

Jerada, Rania and Er-Rakibi, Abdeljalil and Hassani, Abha Cherkani and Benzeid, Hanane and El Ouardi, Abdelmoula and Harhar, Hicham and Goh, Bey Hing * and Yow, Yoon Yen * and Ser, Hooi Leng * and Bouyahya, Abdelhakim and Mojemmi, Brahim and Doukkali, Anass (2024) A comprehensive review on ethnomedicinal uses, phytochemistry, toxicology, and pharmacological activities of Dittrichia viscosa (L.) Greuter. Journal of Traditional and Complementary Medicine. ISSN 2225-4110 (In Press)

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Official URL: https://doi.org/10.1016/j.jtcme.2024.03.012


Dittrichia viscosa is a perennial herb that has been used for generations in traditional medicine to address a variety of diseases, including diabetes, hypertension, cancer, microbial disorders, inflammatory conditions, and wound healing. The objective of this review is to provide an overview of existing knowledge on D. viscosa with regards to its botanical description, ethnomedicinal uses, and pharmacological properties. Databases such as Scopus, Wiley-Online, PubMed, Springer, Google Scholar, and ScienceDirect were used to select relevant articles based on their title and abstract. The reviewed studies found a strong correlation between D. viscosa's traditional uses and its observed biological effects. Pharmacological research has shown that the essential oils and extracts from D. viscosa possess a variety of biological activities, such as anti-inflammatory, anticancer, antibacterial, antifungal, analgesic, and antioxidant properties. The chemical compounds found in D. viscosa include sesquiterpenes, monoterpenes, flavonoids, and phenolic acids; some of these compounds, such as tometosin and inuviscolide, have been isolated and displayed promising cytotoxic and anti-inflammatory activity. The present review suggests that the pharmacological properties of D. viscosa align well with its ethnomedicinal uses. These findings support the traditional use of D. viscosa in treating various illnesses. Additionally, toxicological examinations of D. viscosa extracts and essential oil have demonstrated the plant's safety, which supports the need for comprehensive pharmacological studies, in vivo studies, and clinical trials to evaluate the best doses for optimal medicinal effects. This work underscores the medicinal value of D. viscosa and its potential in developing new pharmacological agents to address major health challenges like antibiotic resistance and cancers.

Item Type: Article
Uncontrolled Keywords: dittrichia viscosa; ethnomedicine; pharmacology; phytochemistry; toxicology;
Subjects: G Geography. Anthropology. Recreation > GN Anthropology
Q Science > QK Botany
R Medicine > RA Public aspects of medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020]
Depositing User: Ms Yong Yee Chan
Related URLs:
Date Deposited: 16 May 2024 01:40
Last Modified: 16 May 2024 01:40
URI: http://eprints.sunway.edu.my/id/eprint/2613

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