Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments

Aquili, Luca * and Liu, Andrew W. and Shindou, Mayumi and Shindou, Tomomi and Wickens, Jeffrey R. (2014) Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments. Learning & Memory, 21 (4). pp. 223-231. ISSN 1072-0502

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Abstract

Behavioral flexibility is vital for survival in an environment of changing contingencies. The nucleus accumbens may play an important role in behavioral flexibility, representing learned stimulus–reward associations in neural activity during response selection and learning from results. To investigate the role of nucleus accumbens neural activity in behavioral flexibility, we used light-activated halorhodopsin to inhibit nucleus accumbens shell neurons during specific time segments of a bar-pressing task requiring a win–stay /lose–shift strategy. We found that optogenetic inhibition during action selection in the time segment preceding a lever press had no effect on performance. However, inhibition occurring in the time segment during feedback of results—whether rewards or nonrewards—reduced the errors that occurred after a change in contingency. Our results demonstrate critical time segments during which nucleus accumbens shell neurons integrate feedback into subsequent responses. Inhibiting nucleus accumbens shell neurons in these time segments, during reinforced performance or after a change in contingencies, increases lose–shift behavior. We propose that the activity of nucleus shell accumbens shell neurons in these time segments plays a key role in integrating knowledge of results into subsequent behavior, as well as in modulating lose–shift behavior when contingencies change.

Item Type: Article
Additional Information: First author is with the Dept. of Psychology, Faculty of Science and Technology, Sunway University; other authors are with Okinawa Institute of Science and Technology Graduate University, Neurobiology Research Unit.
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QP Physiology
Divisions: Sunway University > School of Science and Technology > Dept. Psychology
Depositing User: Ms. Molly Chuah
Date Deposited: 01 Apr 2015 07:29
Last Modified: 01 Apr 2015 07:29
URI: http://eprints.sunway.edu.my/id/eprint/259

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