Synthesis, characterization and antibacterial evaluation of Bismuth(III) Xanthate

Ooi, Zhi Yao (2020) Synthesis, characterization and antibacterial evaluation of Bismuth(III) Xanthate. Masters thesis, Sunway University.

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Since antibiotic resistance is inevitable and the discovery for new antibiotics is decelerating, different opportunities are being explored to withstand against this issue. Earlier studies showed that metal complexes with dithiolate ligands, such as xanthates and bismuth metal, have an expansive range of applications as pesticides, antidiarrheal, antioxidant, and antiviral. The antibacterial activity of bismuth(III) xanthate complexes remained anonymous. In this study, a bismuth(III) xanthate series, with different alkyl substituents, were synthesized. Then, the end-products were characterized, using diverse instruments, such as nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy, elemental analyzer, and X-ray crystallography. The antibacterial evaluation of this series was executed, using disc diffusion method, broth microdilution method and time-kill assay. Based on the results, a majority of the bismuth(III) xanthate complexes exhibited mild antibacterial effect against different bacteria tested. Among all the complexes tested, the complexes with isopropyl and butyl xanthate ligand derivatives exhibited effective antibacterial activity and were bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), after 4 hours of incubation. Based on the cytotoxicity test performed, using the 3-(4,5-dimethylthiazol-2-yl)-2–5-diphenyltetrazolium bromide (MTT) assay against human embryonic kidney cells (HEK-293) and it was proved that the bismuth(III) xanthate complexes were moderately toxic towards HEK-293 cells. In conclusion, bismuth(III) xanthate complexes might not be promising candidates as antimicrobial agents, as they are mildly active against some clinically important pathogens and moderately toxic against human cells.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bismuth(III) Xanthate; synthesis; characterization; antibacterial; metal complexes; antimicrobial properties; antimicrobial agent.
Subjects: R Medicine > RB Pathology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Sunway University > School of Engineering and Technology [formerly School of Science and Technology until 2020] > Dept. Biological Sciences moved to SMLS wef 2021
Depositing User: Ms Yong Yee Chan
Date Deposited: 05 Oct 2023 03:14
Last Modified: 05 Oct 2023 03:14

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