Carotenoids: Role in Neurodegenerative Diseases Remediation

Gandla, Kumaraswamy and Babu, Ancha Kishore and Unnisa, Aziz and Sharma, Indu and Singh, Laliteshwar Pratap and Haque, Mahammad Akiful and Dashputre, Neelam Laxman and Baig, Shahajan and Siddiqui, Falak A. and Khandaker, Mayeen Uddin * and Almujally, Abdullah and Tamam, Nissren and Sulieman, and Khan, Sharuk L. and Emran, Talha Bin (2023) Carotenoids: Role in Neurodegenerative Diseases Remediation. Brain Sciences, 13 (3). p. 457. ISSN 2076-3425

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Abstract

Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of several brain illnesses. CTs are organic pigments with major significance in ND prevention. More than 600 CTs have been discovered in nature, and they may be found in a wide variety of creatures. Different forms of CTs are responsible for the red, yellow, and orange pigments seen in many animals and plants. Because of their unique structure, CTs exhibit a wide range of bioactive effects, such as anti-inflammatory and antioxidant effects. The preventive effects of CTs have led researchers to find a strong correlation between CT levels in the body and the avoidance and treatment of several ailments, including NDs. To further understand the connection between OS, neuroinflammation, and NDs, a literature review has been compiled. In addition, we have focused on the anti-inflammatory and antioxidant properties of CTs for the treatment and management of NDs.

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