Innate and adaptive immune evasion by dengue virus

Lee, Michelle Felicia * and Voon, Guan Zhong * and Lim, Hui Xuan * and Chua, Mun Lok * and Poh, Chit Laa * (2022) Innate and adaptive immune evasion by dengue virus. Frontiers in Cellular and Infection Microbiology, 12. ISSN 2235-2988

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Dengue is a mosquito-borne disease which causes significant public health concerns in tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to manipulate the innate immune responses of the host such as ‘hiding’ in the ultrastructure of the host, interfering with the signaling pathway through RNA modifications, inhibiting type 1 IFN production, as well as inhibiting STAT1 phosphorylation. DENV is also able to evade the adaptive immune responses of the host through antigenic variation, antigendependent enhancement (ADE), partial maturation of prM proteins, and inhibition of antigen presentation. miRNAs are important regulators of both innate and adaptive immunity and they have been shown to play important roles in DENV replication and pathogenesis. This makes them suitable candidates for the development of anti-dengue therapeutics. This review discusses the various strategies employed by DENV to evade innate and adaptive immunity. The role of miRNAs and DENV non-structural proteins (NS) are promising targets for the development of anti-dengue therapeutics.

Item Type: Article
Uncontrolled Keywords: dengue virus; innate immunity; adaptive immunity; immune evasion; interferon
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre for Virus and Vaccine Research [dissolved]
Depositing User: Ms Yong Yee Chan
Related URLs:
Date Deposited: 20 Mar 2023 03:34
Last Modified: 20 Mar 2023 03:34

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