Molecular Mechanisms of Antiviral Agents against Dengue Virus

Lee, Michelle Felicia and Wu, Yuan Seng and Poh, Chit Laa * (2023) Molecular Mechanisms of Antiviral Agents against Dengue Virus. Viruses, 15 (3). p. 705. ISSN 1999-4915

molecular mechanisms of antiviral agents against dengue virus.pdf - Published Version
Available under License Creative Commons Attribution.

Download (4MB) | Preview
Official URL:


Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics. Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed. In addition, the development of antivirals that target different stages during post-infection such as viral replication, viral maturation, and viral assembly are reviewed. Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections. Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.

Item Type: Article
Uncontrolled Keywords: flavivirus; dengue virus; antiviral; small molecule; peptide; phytochemicals; mechanism of action
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Others > Non Sunway Academics
Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Centre for Virus and Vaccine Research [dissolved]
Depositing User: Ms Yong Yee Chan
Related URLs:
Date Deposited: 20 Mar 2023 03:14
Last Modified: 20 Mar 2023 03:14

Actions (login required)

View Item View Item