Muhammad Syafiq, Sahari and Tiekink, Edward R. T. * and Dolzhenko, Anton V (2022) One-pot multicomponent synthesis of bis(diamino-1,3,5-triazines) under microwave irradiation. ChemistrySelect, 7 (44). ISSN 2365-6549
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Abstract
A new method for the synthesis of bis(1,3,5-triazine-2,4-diamines) was developed using a one-pot multicomponent approach. The synthesis was performed using the acid-catalyzed reaction of cyanoguanidine with amines and aldehydes, followed by dehydrogenative aromatization of the dihydrotriazine intermediates upon heating with alkali. Two types of bis(1,3,5-triazine-2,4-diamines) were prepared using either piperazine as the bifunctional amine or terephthaldehyde as the bifunctional aldehyde thus affording products with a piperazine or p-phenylene link between two 1,3,5-triazine rings. The microwave-assisted method allows fast and convenient synthesis of diverse bis(1,3,5-triazine-2,4-diamines).
| Item Type: | Article |
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| Uncontrolled Keywords: | Triazines; multicomponent reactions; microwave-assisted synthesis; antileukemic activity; 3D-QSAR; microwave chemistry; dehydrogenative aromatization |
| Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Others > Non Sunway Academics Sunway University > School of Medical and Life Sciences [formerly School of Healthcare and Medical Sciences until 2020] > Sunway Biofunctional Molecules Discovery Centre [formerly Research Centre for Crystalline Materials until 2023] |
| Depositing User: | Ms Yong Yee Chan |
| Related URLs: | |
| Date Deposited: | 23 Nov 2022 03:06 |
| Last Modified: | 23 Nov 2022 03:06 |
| URI: | http://eprints.sunway.edu.my/id/eprint/2130 |
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