Beta-actin variant is necessary for Enterovirus 71 replication

Lui, Edmund Yan Long and Lin, Zhiyang and Lee, Jia Jun and Chow, Vincent Tak Kwong and Poh, Chit Laa * and Tan, Eng Lee (2013) Beta-actin variant is necessary for Enterovirus 71 replication. Biochemical and Biophysical Research Communications, 433 (4). pp. 607-610. ISSN 0006-291X

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Abstract

Enterovirus 71 (EV71) is one of the main etiological agents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complications such as herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. EV71 is endemic in the Asia-Pacific region and causes occasional epidemics. In order to better understand EV71 infection, we compared the proteome between EV71-susceptible and EV71-resistant human Rhabdomyosarcom a(RD)cell line. We found significant differences in the b-actin variants between the EV71-susceptible RD cells and EV71-resistant RD cells, suggesting that b-actin, in association with other proteins such as annexin 2 is required in vesicular transport of EV71. This finding further support our previous study that actin potentially plays a role in pathogenesis and the establishment of the disease in HFMD.

Item Type: Article
Additional Information: First, 3rd and 6th authors are affiliated with Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore; 2nd author with College of Medicine, Biology and Environment, Australian National University, Canberra, Australia; 4th author with Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 5th author with Dept. Biological Sciences, Sunway University.
Uncontrolled Keywords: Hand, Foot and Mouth Disease; Potentially fatal Enterovirus 71; Beta-actin; Annexin 2; Rhabdomyosarcoma cell
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Others > Non Sunway Academics
Sunway University > School of Science and Technology > Dept. Biological Sciences
Depositing User: Ms. Molly Chuah
Date Deposited: 11 Jan 2014 12:50
Last Modified: 11 Jan 2014 12:50
URI: http://eprints.sunway.edu.my/id/eprint/196

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